Publications

1. Cardioprotection by the adiponectin receptor agonist ALY688 in a preclinical mouse model of heart failure with reduced ejection fraction (HFrEF).
👉  Biomed Pharmacother

2. MitoNEET provides cardioprotection via reducing oxidative damage and conserving mitochondrial function
👉  Int J Mol Sci

3. Crosstalk between myocardial autophagy and sterile inflammation in the development of heart failure.
👉  Autophagy Reports 

4. Disrupted Autophagy Flux in Adiponectin Knockout Mice Exacerbates Ischemia-Induced Heart Failure
👉  Clinical and Translational Science (Accepted; in press)

5. A sustained release form of adiponectin-derived peptide ALY688 protects against the development of non-alcoholic steatohepatitis.  
👉  Clinical and Translational Science 

6. Salubrinal promotes phospho-eif2a-dependent activation of UPR leading to autophagy-mediated alleviation of iron overload-induced insulin resistance.
👉  Molecular Metabolism

7. A novel blood-based bioassay to monitor adiponectin signaling. 
👉  International Immunopharmacology 

8. MitoNEET preserves muscle insulin sensitivity during iron overload by regulating mitochondrial iron, reactive oxygen species and fission
👉 FEBS Journal  

9. Impaired autophagic flux contributes to diabetic ischemia reperfusion injury in the heart.
👉 Autophagy Reports

10. Ischemia-induced cardiac dysfunction is exacerbated in adiponectin-knockout mice due to impaired autophagy flux
👉 Clin Transl Sc

11. Screening for blood-borne biomarkers of adiponectin action using the receptor agonist ALY688
👉 iScience (2024: accepted, in press)

12. Recent advances in developing adiponectin therapies for Duchenne muscular dystrophy
👉 Biomedicines

13. The slow-release adiponectin analog ALY688-SR modifies early-stage disease development in the D2. mdx mouse model of Duchenne muscular dystrophy
👉 Am J Physiol Cell Physiol

 

1. Discovery-Based Proteomics Identify Skeletal Muscle Mitochondrial Alterations as an Early Metabolic Defect in a Mouse Model of β-Thalassemia
👉  Int. J. Mol. Sci.

2. Autophagy deficiency exacerbates iron overload induced reactive oxygen species production and apoptotic cell death in skeletal muscle cells
👉  Cell Death Dis

3. Sterile inflammation and the NLRP3 inflammasome in cardiometabolic disease
👉  Biomed J

4. MitoNEET prevents iron overload-induced insulin resistance in H9c2 cells through
regulation of mitochondrial iron.
👉  J Cell Physiol

5. Perturbations in lipid metabolism and gut microbiota composition precede cardiac dysfunction in a mouse model of thalassemia.
👉  FASEB J

6. Copper Fabric Attenuates Inflammation in Macrophages
👉  PLoS One

7. Memory impairment in the D2.mdx mouse model of Duchenne muscular dystrophy is prevented by the adiponectin receptor agonist ALY688-SR
👉  Exp Physiol

 

 

1. ALY688 elicits adiponectin-mimetic signaling and improves insulin action in skeletal muscle cells
👉  Am J Physiol Cell Physiol

2. Copper fabric improves the metabolic profile of obese mice: Potential role of the gut microbiota

👉  Basic Clin Pharmacol Toxicol

3. Importance of Autophagy in Mediating Cellular Responses to Iron Overload in Cardiomyocytes

👉 Reviews in Cardiovascular Medicine

4. FGF21-Sirtuin 3 Axis Confers the Protective Effects of Exercise Against Diabetic Cardiomyopathy by Governing Mitochondrial Integrity

👉  Circulation

5. Role of Mitochondrial Iron Overload in Mediating Cell Death in H9c2 Cells

👉  Cells

1. Identification of circulating endocan-1 and ether phospholipids as biomarkers for complications in thalassemia patients
👉  Metabolites

2. Cardiac autophagy deficiency attenuates ANP production and disrupts myocardial-adipose crosstalk leading to increased fat accumulation and metabolic dysfunction

👉  Diabetes

3. Iron increases transendothelial adiponectin flux via inducing ROS production

👉 Biochim Biophys Acta Gen Subj

4. Adiponectin synthesis, secretion and extravasation from circulation to interstitial space

👉 Physiology (Bethesda)

5. Iron overload reduces adiponectin receptor expression via a ROS/FOXO1-dependent mechanism leading to adiponectin resistance in skeletal muscle cells

👉  J Cell Physiol

6. Guidelines for the use and interpretation of assays to monitor autophagy (4th edition)

👉  Autophagy

7. Iron reshapes the gut microbiome and consequently host metabolism

👉  J Lipid Atheroscler

8. Inhibitory effects of terrein on lung cancer cell metastasis and angiogenesis

👉  Oncol Rep

1. Empagliflozin Blunts Worsening Cardiac Dysfunction Associated With Reduced NLRP3 (Nucleotide-Binding Domain-Like Receptor Protein 3) Inflammasome Activation in Heart Failure

👉 Atherosclerosis

2. An adiponectin-S1P autocrine axis protects skeletal muscle cells from palmitate-induced cell death

👉 Lipids in Health and Disease

3. A Unique Conformational Distortion Mechanism Drives Lipocalin 2 Binding to Bacterial Siderophores.

👉 ACS Chemical Biology

4. Effects of the adiponectin mimetic peptide ALY688 on glucose and fat metabolism in visceral and subcutaneous rat adipocytes

👉 Adipocyte

5. Regulatory connections between iron and glucose metabolism

👉 International Journal of Medical Sciences

6. Dietary sucrose induces metabolic inflammation and atherosclerotic cardiovascular diseases more than dietary fat in LDLr -/- ApoB 100/100 mice

👉 Circ Heart Fail

1. A Unique Conformational Distortion Mechanism Drives Lipocalin 2 Binding to Bacterial Siderophores

👉 ACS Chem Biol

2. Tracking adiponectin biodistribution via fluorescence molecular tomography indicates increased vascular permeability after streptozotocin-induced diabetes

👉 Am J Physiol Endocrinol Metab 

3. Iron overload inhibits late stage autophagic flux leading to insulin resistance

👉 EMBO Rep

4. An adiponectin-S1P axis protects against lipid induced insulin resistance and cardiomyocyte cell death via reduction of oxidative stress

👉 Nutr Metab (Lond) 

5. Examining the Potential of Developing and Implementing Use of Adiponectin-Targeted Therapeutics for Metabolic and Cardiovascular Diseases

👉 Front Endocrinol (Lausanne) 

6. Iron induces insulin resistance in cardiomyocytes via regulation of oxidative stress

👉 Sci Rep

1. Holo-lipocalin-2–derived siderophores increase mitochondrial ROS and impair oxidative phosphorylation in rat cardiomyocytes

👉 Proc Natl Acad Sci U S A

1. Heart Failure and MEF2 Transcriptome Dynamics in Response to β-Blockers

👉 Sci Rep

2. Lipocalin-2 (NGAL) Attenuates Autophagy to Exacerbate Cardiac Apoptosis Induced by Myocardial Ischemia

👉 J Cell Physiol

3. Lipocalin-2 induces NLRP3 inflammasome activation via HMGB1 induced TLR4 signaling in heart tissue of mice under pressure overload challenge

👉 Am J Transl Res

4. Transendothelial movement of adiponectin is restricted by glucocorticoids

👉 J Endocrinol

5. Adiponectin improves insulin sensitivity via activation of autophagic flux

👉 J Mol Endocrinol

1. The association between PGC-1α and Alzheimer’s disease

👉 Anat Cell Biol

2. Crosstalk between the heart and peripheral organs in heart failure

👉 Exp Mol Med

3. Cellular, structural and functional cardiac remodelling following pressure overload and unloading

👉 Int J Cardiol

4. Lipocalin-2 inhibits autophagy and induces insulin resistance in H9c2 cells

👉 Mol Cell Endocrinol

1. Biomarkers of insulin sensitivity and insulin resistance: Past, present and future

👉 Crit Rev Clin Lab Sci

2. Metabolomic profiling in liver of adiponectin-knockout mice uncovers lysophospholipid metabolism as an important target of adiponectin action

👉 Biochem J

3. Pressure Overload-Induced Cardiac Dysfunction in Aged Male Adiponectin Knockout Mice Is Associated With Autophagy Deficiency

👉 Endocrinology

4. Adiponectin is required for cardiac MEF2 activation during pressure overload induced hypertrophy

👉 J Mol Cell Cardiol

5. Temporal and Molecular Analyses of Cardiac Extracellular Matrix Remodeling following Pressure Overload in Adiponectin Deficient Mice

👉 PLoS One

6. Iron metabolism and regulation by neutrophil gelatinase-associated lipocalin in cardiomyopathy

👉 Clin Sci (Lond)

7. Adiponectin stimulates autophagy and reduces oxidative stress to enhance insulin sensitivity during high-fat diet feeding in mice

👉 Diabetes

8. Emerging role of autophagy in mediating widespread actions of ADIPOQ/adiponectin.

👉 Autophagy

9. Palmitate induces ER stress and autophagy in H9c2 cells: implications for apoptosis and adiponectin resistance

👉 Journal of Cellular Physiology 

10. The molecular basis of the antidiabetic action of quercetin in cultured skeletal muscle cells and hepatocytes

👉 Pharmacognosy Magazine

1. APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice

👉  Diabetes

2. Adiponectin action in skeletal muscle

👉  Best Practice & Research Clinical Endocrinology & Metabolism

3. Adiponectin mediated APPL1-AMPK signaling induces cell migration, MMP activation, and collagen remodeling in cardiac fibroblasts

👉  Journal of Cellular Biochemistry

4. Altered Transendothelial Transport of Hormones as a Contributor to Diabetes

👉  Diabetes Metabolism Journal

5. Adiponectin stimulates Rho-mediated actin cytoskeleton remodeling and glucose uptake via APPL1 in primary cardiomyocytes

👉  Metabolism: Clinical and Experimetnal

6. Early development of calcific aortic valve disease and left ventricular hypertrophy in a mouse model of combined dyslipidemia and type 2 diabetes

👉  Arterioscler Thromb Vasc Biol

7. The furan fatty acid metabolite CMPF is elevated in diabetes and induces beta cell dysfunction

👉  Cell metabolism

8. The adaptor protein APPL2 inhibits insulin-stimulated glucose uptake by interacting with TBC1D1 in skeletal muscle

👉  Diabetes

9. Skeletal muscle glucose metabolism and inflammation in the development of the metabolic syndrome

👉  Reviews in Endocrine and Metabolic Disorders

10. The role of adiponectin signaling in metabolic syndrome and cancer

👉  Reviews in Endocrine and Metabolic Disorder 

11. Regulation of Iron and Its Significance in Obesity and Complications

👉  Korean J Obes

1. Adiponectin corrects high fat diet-induced disturbances in muscle metabolomic profile and whole body glucose homeostasis

👉  Diabetes

2. Tissue specific delivery of adiponectin gene to skeletal muscle using ultrasound targeted microbubble gene delivery is sufficient to improve whole body glucose homeostasis.

👉  American Journal of Physiology:Endocrinology & Metabolism

3. APPL1 Transgenic Mice Are Protected From High Fat Diet-Induced Cardiomyopathy

👉  American Journal of Physiology:Endocrinology & Metabolism

4. Globular adiponectin induces LKB1/AMPK-dependent glucose uptake via actin cytoskeleton remodeling

👉  Journal of Molecular Endocrinology

5. Metabolomic profiling as a useful tool for diagnosis and treatment of chronic disease: focus on obesity, diabetes and cardiovascular diseases

👉  Expert Review of Cardiovascular Therapy

6.Distinct metabolic and vascular effects of dietary triglycerides and cholesterol in atherosclerotic and diabetic mouse models.

👉  American Journal of Physiology:Endocrinology & Metabolism

7. TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt.

👉  Biochemical Journal

8. The genetic and metabolic determinants of cardiovascular complications in type 2 diabetes: recent insights from animal models and clinical investigations

👉  Canadian Journal of Diabetes

1. Direct effects of adipokines on the heart: focus on adiponectin

👉  Heart Failure Reviews

2. Diabetes influences cardiac extracellular matrix remodeling after myocardial infarction and subsequent development of cardiac dysfunction

👉  Journal of Cellular and Molecular Medicine

3. Ischemia-reperfusion injury leads to distinct temporal cardiac remodeling in normal versus diabetic mice.

👉  PLoS One

4. Modulation of the cardiovascular system by leptin

👉 Biochimie

5. Lipocalin-2 induces cardiomyocyte apoptosis by increasing intracellular iron accumulation

👉  Journal of Biological Chemistry

6. Emerging clinical and experimental evidence for the role of lipocalin-2 in metabolic syndrome

👉  Clinical and Experimental Physiology & Pharmacology

7. APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice.

👉  Proc Natl Acad Sci USA.

8. Effects of moderate electrical stimulation on reactive species production by primary rat skeletal muscle cells: relationship between superoxide and nitric oxide production

👉  Journal of Cellular Physiology

9. Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: restoration of mitochondrial function and phospholipids remodeling.

👉  American Journal of Translational Research

10. Circulating and PBMC Lp-PLA2 associate differently with oxidative stress and subclinical inflammation in nonobese women (menopausal status).

👉  PLoS One.

1. APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice

👉  Diabetes

2. Adiponectin increases LPL activity via RhoA/ROCK-mediated actin remodelling in adult rat cardiomyocytes.

👉  Endocrinology

3. Adiponectin prevents hypoxia/reoxygenation-induced apoptosis in cardiomyocytes via AdipoR1/APPL1 signaling.

👉  PLoS One 

4. Regulation of MT1-MMP by leptin in cardiac fibroblasts involves RhoA/ROCK-dependent cytoskeletal reorganization and is associated with altered MMP-2 activity.

👉  Endocrinology

5. Cardiovascular complications of diabetes: recent insights in pathophysiology and therapeutics

👉  Expert Reviews in Endocrinology & Metabolism

6. Adiponectin action: a combination of endocrine and autocrine/paracrine effects.

👉  Frontiers in Cellular Endocrinology

7. Selective inactivation of c-Jun NH2 terminal kinase in adipose tissue protects against diet-induced obesity and improves insulin sensitivity in both liver and skeletal muscle in mice.

👉  Diabetes

8. Carnitine palmitoyltransferase-1A prevents free fatty acid induced adipocyte dysfunction through suppression of c-Jun N-terminal kinase

👉  Biochemical Journal

9. Association of Lp-PLA2 activity and LDL size with interleukin-6, an inflammatory cytokine and oxidized LDL, a marker of oxidative stress in women with metabolic syndrome.

👉  Atherosclerosis 

10. Absence of equilibrative nucleoside transporter 1 in ENT1 knockout mice leads to altered nucleoside levels following hypoxic challenge.

👉  Life Science

 

1. Cardiovascular effects of leptin.

👉  Nature Reviews Cardiology

2. An APPL1-AMPK signaling axis mediates beneficial metabolic effects of adiponectin in the heart

👉  American Journal of Physiology:Endocrinology & Metabolism

3. Protection against developing insulin resistance in mice lacking lipocalin-2.

👉  Diabetes

4. Functional and mechanistic integration of infection and the metabolic syndrome

👉  Korean Diabetes Journal

5. Temporal analysis of mechanisms leading to stimulation of glucose uptake in skeletal muscle cells by an adipokine mixture derived from primary rat adipocytes

👉  International Journal of Obesity

6. Leptin regulates MMP-2, TIMP-1 and collagen synthesis via p38 MAPK in HL-1 murine cardiomyocytes

👉  Cell & Molecular Biology Letters

7. Equilibrative nucleoside transporter 1 plays an essential role in cardioprotection

👉  American Journal of Physiology: Heart & Circ

8. Serum Ferritin Was linked with Aortic Stiffness in apparently healthy Korean Women

👉  Critical Pathways in Cardiology